Highway 154 was shut down Friday night after a multi-vehicle crash near Lake Cachuma, according to the Santa Barbara County Fire Department.
Six vehicle were involved in the collision that occurred at about 8:40 p.m., said fire Capt. Scott Safechuck.
Three people sustained minor injuries, Safechuck said, but none of them required hospitalization.
Five tow trucks were requested to remove the wreckage, which was blocking both lanes of the highway, according to the California Highway Patrol.
The roadway was partially reopened at about 10:20 p.m., with alternating traffic.
Cause of the crash was under investigation by the CHP.